Publications

This section provides a list of publications related to Heta language and its applications in Quantitative Systems Pharmacology (QSP) and Systems Biology.

• Borisov, I., Demin, A., Metelkin, E., (2026). LikelihoodProfiler.jl: Unified profile-likelihood workflows for identifiability and confidence intervals. Journal of Open Source Software. DOI: 10.21105/joss.09501

• Maliukova, P., Karelina, T. A., (2025). A Quantitative Systems Pharmacology Model That Describes Neurofilament Light Dynamics During Alzheimer's Disease Progression. CPT: Pharmacometrics & Systems Pharmacology. DOI: 10.1002/psp4.70062

• Bajaj, G., Shchelokov, D., Demin, O. Jr., Thalhauser, C., (2025). Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data. Clinical Pharmacology & Therapeutics. DOI: 10.1002/cpt.3677

• Demin, O., Ou, Y., Kolesova, G., Hanley, W. D., (2025). Quantitative Systems Pharmacology Model to Predict Target Occupancy by Bruton Tyrosine Kinase Inhibitors in Patients With B‐Cell Malignancies. CPT: Pharmacometrics & Systems Pharmacology. DOI: 10.1002/psp4.13307

• Shchelokov, D., Demin, O. Jr., (2022). Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study. mAbs. DOI: 10.1080/19420862.2022.2156317

• Metelkin, E., Borisov, I., (2022). Parameters Estimation, Identifiability and Predictability Analysis in Systems Biology with HetaSimulator and LikelihoodProfiler PAGE2022 Abstract Book. DOI: 10.13140/RG.2.2.16100.24967

• Metelkin, E., Borisov, I., (2022). Dynamic and reproducible reports for QSP modeling in R and Julia: working examples QSP Conference 2022 Abstract Book. DOI: 10.13140/RG.2.2.12619.05921

• Metelkin, E., (2021). Heta compiler: a software tool for the development of large-scale QSP models and compilation into simulation formats. Journal of Open Source Software, 6(67), 3708. DOI: 10.21105/joss.03708

• Borisov, I., Metelkin, E., (2021). HetaProject – a Single Open Source Platform for Modeling, Simulation and Parameters Estimation in QSP. PAGE 2021 Abstract Book. DOI: 10.13140/RG.2.2.31275.77608, DOWNLOAD

• Metelkin, E., (2021). Heta language: Modularity and Reusability in QSP modeling platforms. ACoP12 Abstract Book. DOI: 10.13140/RG.2.2.16900.04484, DOWNLOAD

• Metelkin, E., (2019). "Heta" is a New Declarative Language to Define the Large-Scale Systems Pharmacology and Systems Biology Models ACoP10 Abstract Book. DOI: 10.13140/RG.2.2.14881.35682